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"Disease Eradication"
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Have bacteria won?
Today, we are far less likely to die from infection than at any other time in history, but still we worry about epidemics, the menace of antibiotic resistance and modern \"plagues\" like Ebola. In this timely new book, eminent bacteriologist Hugh Pennington explores why these fears remain and why they are unfounded. He reports on outright victories (such as smallpox), battles where the enemy is on its last stand (polio), surprise attacks from vegetarian bats (Ebola, SARS) and demented cows (BSE). Qualified optimism, he argues, is the message for the future but the battles will go on forever. -- Provided by publisher.
Book
Challenges and opportunities for control and elimination of soil-transmitted helminth infection beyond 2020
[...]as we turn our sights towards and beyond 2020, the Committee recognized it as timely to review and assess the successes and challenges of progress made to date. PC, preventive chemotherapy; PSAC, preschool children; WHO, World Health Organization. https://doi.org/10.1371/journal.pntd.0007201.g002 There have been many important developments by the time the Committee convened in November 2017, but six are particularly noteworthy: * updated PC guidelines published by WHO for all at-risk populations [13]; * the Bellagio Declaration focusing on girls and WRA [14]; * widening of WHO’s engagement with experts around the globe [15]; * success of the Global Program to Eliminate Lymphatic Filariasis (GPELF) [16]; * increasing importance for deworming programs to measure impact [17]; and * the launch by WHO-AFRO of the Expanded Special Project on the Elimination of Neglected Tropical Diseases (ESPEN) portal (http://espen.afro.who.int), which provides—for the first—subnational data on disease endemicity and PC coverage for each of the five PC-NTDs, including STH infection. Current approaches to measuring impact vary across countries and across deworming program implementers, limiting comparability and the possibility to appreciate changes over time and across countries and regions. [...]impact data are not readily available, with most of the evaluations conducted by research groups. Consistent with these needs is a recognized gap in our current knowledge of disease transmission at low prevalence and persistent environmental factors that facilitate transmission. [...]there is a renewed need to clearly identify research gaps and questions that would facilitate implementation in these settings.
Journal Article
Countdown to 2030: eliminating hepatitis B disease, China
Hepatitis B virus (HBV) infection is a major public health problem worldwide. China has the world's largest burden of HBV infection and will be a major contributor towards the global elimination of hepatitis B disease by 2030. The country has made good progress in reducing incidence of HBV infection in the past three decades. The achievements are mainly due to high vaccination coverages among children and high coverage of timely birth-dose vaccine for prevention of mother-to-child transmission of HBV (both > 95%). However, China still faces challenges in achieving its target of 65% reduction in mortality from hepatitis B by 2030. Based on targets of the World Health Organization's
, we highlight further priorities for action towards HBV elimination in China. To achieve the impact target of reduced mortality we suggest that the service coverage targets of diagnosis and treatment should be prioritized. First, improvements are needed in the diagnostic and treatment abilities of medical institutions and health workers. Second, the government needs to reduce the financial burden of health care on patients. Third, better coordination is needed across existing national programmes and resources to establish an integrated prevention and control system that covers prevention, screening, diagnosis and treatment of HBV infection across the life cycle. In this way, progress can be made towards achieving the target of eliminating hepatitis B in China by 2030.
Journal Article
The end of plagues : the global battle against infectious disease
\"At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio\"--Provided by publisher.
Book
Malaria eradication and elimination: views on how to translate a vision into reality
Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication a reality.
Journal Article
The World Health Organization : a history
\"According to its Constitution, the mission of the World Health Organization (WHO) was nothing less than the 'attainment by all peoples of the highest possible level of health' without distinction of race, religion, political belief, economic status, or social condition. But how consistently and how well has the WHO pursued this mission since 1946? This comprehensive and engaging new history explores these questions by looking at its origins and its institutional antecedents, while also considering its contemporary and future roles. It examines how the WHO was shaped by the particular environments of the postwar period and the Cold War, the relative influence of the US and other approaches to healthcare, and its place alongside sometimes competing international bodies such as UNICEF, the World Bank, and the Gates Foundation. The authors re-evaluate the relative success and failure of critical WHO campaigns, from early malaria and smallpox eradication programs to struggles with Ebola today.\"--Back cover.
Book
Global Polio Eradication Initiative: Lessons Learned and Legacy
The world is on the verge of achieving global polio eradication. During >25 years of operations, the Global Polio Eradication Initiative (GPEI) has mobilized and trained millions of volunteers, social mobilizers, and health workers; accessed households untouched by other health initiatives; mapped and brought health interventions to chronically neglected and underserved communities; and established a standardized, real-time global surveillance and response capacity. It is important to document the lessons learned from polio eradication, especially because it is one of the largest ever global health initiatives. The health community has an obligation to ensure that these lessons and the knowledge generated are shared and contribute to real, sustained changes in our approach to global health. We have summarized what we believe are 10 leading lessons learned from the polio eradication initiative. We have the opportunity and obligation to build a better future by applying the lessons learned from GPEI and its infrastructure and unique functions to other global health priorities and initiatives. In so doing, we can extend the global public good gained by ending for all time one of the world's most devastating diseases by also ensuring that these investments provide public health dividends and benefits for years to come.
Journal Article
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication
ObjectiveHelicobacter pylori is associated with gastric inflammation, precancerous gastric atrophy (GA) and intestinal metaplasia (IM). We aimed to identify microbes that are associated with progressive inflammation, GA and IM 1 year after H. pylori eradication.DesignA total of 587 H.pylori–positive patients were randomised to receive H. pylori eradication therapy (295 patients) or placebo (292 patients). Bacterial taxonomy was analysed on 404 gastric biopsy samples comprising 102 pairs before and after 1 year H. pylori eradication and 100 pairs before and after 1 year placebo by 16S rRNA sequencing.ResultsAnalysis of microbial sequences confirmed the eradication of H. pylori in treated group after 1 year. Principal component analysis revealed distinct microbial clusters reflected by increase in bacterial diversity (p<0.00001) after H. pylori eradication. While microbial interactions remained largely unchanged after placebo treatment, microbial co-occurrence was less in treated group. Acinetobacter lwoffii, Streptococcus anginosus and Ralstonia were enriched while Roseburia and Sphingomonas were depleted in patients with persistent inflammation 1 year after H. pylori eradication. A distinct cluster of oral bacteria comprising Peptostreptococcus, Streptococcus, Parvimonas, Prevotella, Rothia and Granulicatella were associated with emergence and persistence of GA and IM. Probiotic Faecalibacterium praustznii was depleted in subjects who developed GA following H. pylori eradication. Functional pathways including amino acid metabolism and inositol phosphate metabolism were enriched while folate biosynthesis and NOD-like receptor signalling decreased in atrophy/IM-associated gastric microbiota.ConclusionThis study identified that gastric microbes contribute to the progression of gastric carcinogenesis after H. pylori eradication.
Journal Article